Tert-butyl 2-isobutyl-4,6-dioxopiperidine-1-carboxylate → 6-(2-methylpropyl)piperidine-2,4-dione

HRID 1963108ノート

反応式

HRID 1963108 の反応式
[CH2:1]([CH:5]1[CH2:10][C:9](=[O:11])[CH2:8][C:7](=[O:12])[N:6]1C(OC(C)(C)C)=O)[CH:2]([CH3:4])[CH3:3]>O1CCOCC1.Cl>[CH2:1]([CH:5]1[NH:6][C:7](=[O:12])[CH2:8][C:9](=[O:11])[CH2:10]1)[CH:2]([CH3:4])[CH3:3]

参加物

4

反応物 1

HCID 25193505Tert-butyl 2-isobutyl-4,6-dioxopiperidine-1-carboxylate

生成物 1

HCID 52466806-(2-methylpropyl)piperidine-2,4-dione収率 74%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 312751,4-Dioxane溶媒

実験手順

To a solution of tert-butyl 2-isobutyl-4,6-dioxopiperidine-1-carboxylate (30 g, 0.114 mol) in dry 1,4 dioxane (300 mL), HCl (3 M in 1,4 dioxane, 100 mL) was added and stirred at room temperature for 3 h. The reaction mixture was concentrated and purified by crystallization using diethyl ether to yield 6-isobutyl-piperidine-2,4-dione (14 g, 74%) as a white solid.

後処理

  1. concentrationThe reaction mixture was concentrated
  2. custompurified by crystallization

出典と根拠

ORDレコード
ord-28b3f65439014170881e12cb196dcaf2
出典データセット
uspto-grants-2013_04
特許番号
US08415378B2

反応ノート

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