Tetrabutylammonium Fluoride → HCID 66732003、化合物

HRID 1963121ノート

反応式

HRID 1963121 の反応式
[Si]([O:8][CH2:9][CH:10]1[CH2:15][CH2:14][N:13]([C:16]([O:18][CH3:19])=[O:17])[CH:12]([CH3:20])[CH2:11]1)(C(C)(C)C)(C)C.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>[OH:8][CH2:9][CH:10]1[CH2:15][CH2:14][N:13]([C:16]([O:18][CH3:19])=[O:17])[CH:12]([CH3:20])[CH2:11]1

参加物

3

反応物 2

HCID 2724141Tetrabutylammonium FluorideHCID 66732037HCID 66732037、化合物

生成物 1

HCID 66732003HCID 66732003、化合物

実験手順

The compound was prepared as described in Reference Compound 4, Step 4 starting from methyl 4-((tert-butyldimethylsilyloxy)methyl)-2-methylpiperidine-1-carboxylate and TBAF (10.65 mL, 10.65 mmol, 1 M in THF). The residue was purified by column chromatography (Biotage 40%-90% gradient EtOAc in heptane, 340 snap column), which resulted in the title compound. 1H NMR (400 MHz, cdcl3) δ 0.95-1.42 (m, 3H), 1.68-1.95 (m, 3H), 3.08 (m, 1H), 3.39-3.53 (m, 2H), 3.61 (m, 1H), 3.68 (s, 3H), 3.71-3.87 (m, 1H), 3.87-4.08 (m, 1H), 4.30-4.62 (m, 1H).

後処理

  1. customThe compound was prepared
  2. customThe residue was purified by column chromatography (Biotage 40%-90% gradient EtOAc in heptane, 340 snap column), which

出典と根拠

ORDレコード
ord-a57e84778faa4b0ba2ef7c95fa90fd72
出典データセット
uspto-grants-2013_04
特許番号
US08415378B2

反応ノート

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