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4'-Fluoro-4-methylbiphenyl-3-amine → 5-Chloro-2-[((2-[(4'-fluoro-4-methylbiphenyl-3-yl)amino]-2-oxoethoxy)acetyl)amino]benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4'-Fluoro-4-methylbiphenyl-3-amine | HCID 46314430 | — |
| 反応物 | 2-(2-((4-Chloro-2-(methoxycarbonyl)phenyl)amino)-2-oxoethoxy)acetic acid | HCID 51039954 | — |
| 生成物 | 5-Chloro-2-[((2-[(4'-fluoro-4-methylbiphenyl-3-yl)amino]-2-oxoethoxy)acetyl)amino]benzoic acid | HCID 44250948 | — |
反応手順
Using the same method as in Example 1-(ii), 4′-fluoro-4-methylbiphenyl-3-amine was reacted with the (2-([4-chloro-2-(methoxycarbonyl)phenyl]amino)-2-oxoethoxy)acetic acid obtained in Example 1-(i) to give 5-chloro-2-[((2-[(4′-fluoro-4-methylbiphenyl-3-yl)amino]-2-oxoethoxy)acetyl)amino]benzoic acid.methyl ester (yield: 96%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08415479B2 |
| 出典データセット | uspto-grants-2013_04 |
| ORD ID | ord-44b223d0dfc4452a925fdcd3a55e9549 |
| 出典メモ | uspto-grants-2013_04 |