化工社化工社 化学情報印刷レポート · 研究参考用
Cesium carbonate → N-ethyl-5-(furan-3-yl)-2-methylaniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | 2-(Furan-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 2773996 | — |
| 反応物 | 5-bromo-N-ethyl-2-methylaniline | HCID 43729699 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N-ethyl-5-(furan-3-yl)-2-methylaniline | HCID 66877311 | 98% |
反応手順
0.69 g (3.20 mmol) of 5-bromo-N-ethyl-2-methylaniline and 0.93 g (4.80 mmol) of 3-furan boronic acid pinacol ester were dissolved in 7 mL of THF. 1.56 g (4.80 mmol) of cesium carbonate and 370 mg (0.32 mmol) of tetrakis(triphenyl phosphine)palladium(0) were added thereto and heated under reflux for 22 hours. After completion of the reaction, filtration was conducted, and the filtrate was condensed. The resulting crude product was separated and purified using silica gel column chromatography to give N-ethyl-5-(furan-3-yl)-2-methylaniline (yield: 98%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08415479B2 |
| 出典データセット | uspto-grants-2013_04 |
| ORD ID | ord-6f317208b33b4f2a8539517b604f631b |
| 出典メモ | uspto-grants-2013_04 |