Hydrochloric Acid → [6-(3-Chloro-pyridin-2-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-yl]-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-amine HCl salt

HRID 19647ノート

反応式

HRID 19647 の反応式
[Cl:1][C:2]1[C:3]([N:8]2[CH2:32][CH2:31][C:11]3[N:12]=[CH:13][N:14]=[C:15]([NH:16][C:17]4[CH:25]=[C:24]5[C:20]([C:21]([CH3:30])([CH3:29])[CH2:22][N:23]5C(=O)C)=[CH:19][CH:18]=4)[C:10]=3[CH2:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1.Cl>CCO>[ClH:1].[Cl:1][C:2]1[C:3]([N:8]2[CH2:32][CH2:31][C:11]3[N:12]=[CH:13][N:14]=[C:15]([NH:16][C:17]4[CH:25]=[C:24]5[C:20]([C:21]([CH3:29])([CH3:30])[CH2:22][NH:23]5)=[CH:19][CH:18]=4)[C:10]=3[CH2:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 59346505HCID 59346505、化合物

生成物 1

HCID 68412802[6-(3-Chloro-pyridin-2-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-yl]-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-amine HCl salt収率 236.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
55 °C

実験手順

A mixture of 1-{6-[6-(3-chloro-pyridin-2-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-ylamino]-3,3-dimethyl-2,3-dihydro-indol-1-yl}-ethanone (30 mg), EtOH (5 mL), and 5N aqueous HCl (1 mL) was stirred at 55° C. for 10 h. The mixture was concentrated in vacue to give the HCl salt as a light yellow solid (35 mg).

後処理

  1. concentrationThe mixture was concentrated in vacue

出典と根拠

ORDレコード
ord-321d8418eebc41bf8eb3b31e5413ba9d
出典データセット
uspto-grants-2010_06
特許番号
US07745451B2

反応ノート

読み込み中…