(2-Thienylmethyl)amine → 3-([1,1'-biphenyl]-4-ylsulfonyl)-N-(2-thienylmethyl)-1,3-thiazolidine-2-carboxamide
反応式
C(OC([N:8]1[CH2:12][CH2:11][S:10][CH:9]1[C:13]([OH:15])=O)=O)(C)(C)C.C1C=CC(/C(/C2C=CC([N+]([O-])=O)=CC=2)=N/O)=CC=1.[C:34]1([C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)[CH:39]=[CH:38][C:37]([S:40](Cl)(=[O:42])=[O:41])=[CH:36][CH:35]=1.[S:50]1[CH:54]=[CH:53][CH:52]=[C:51]1[CH2:55][NH2:56]>>[C:34]1([C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)[CH:39]=[CH:38][C:37]([S:40]([N:8]2[CH2:12][CH2:11][S:10][CH:9]2[C:13]([NH:56][CH2:55][C:51]2[S:50][CH:54]=[CH:53][CH:52]=2)=[O:15])(=[O:42])=[O:41])=[CH:36][CH:35]=1参加物
5
実験手順
Following the general solid phase method as outlined Example 33, starting from 3-(tert-butoxycarbonyl)-1,3-thiazolidine-2-carboxylic acid, Kaiser oxime resin, 1,1′-biphenyl-4-sulfonyl chloride and 2-thienylmethanamine, the title compound was obtained in 94% purity by HPLC.