Benzhydrylamine → N-benzhydryl-3-([1,1'-biphenyl]-4-ylsulfonyl)-1,3-thiazolidine-2-carboxamide

HRID 1964833

反応式

HRID 1964833 の反応式
C(OC([N:8]1[CH2:12][CH2:11][S:10][CH:9]1[C:13]([OH:15])=O)=O)(C)(C)C.[CH:16]1[CH:21]=[CH:20][C:19](/[C:22](/[C:25]2[CH:30]=[CH:29][C:28]([N+]([O-])=O)=[CH:27][CH:26]=2)=[N:23]/O)=[CH:18][CH:17]=1.[C:34]1([C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)[CH:39]=[CH:38][C:37]([S:40](Cl)(=[O:42])=[O:41])=[CH:36][CH:35]=1.C(N)(C1C=CC=CC=1)C1C=CC=CC=1>>[CH:22]([NH:23][C:13]([CH:9]1[N:8]([S:40]([C:37]2[CH:36]=[CH:35][C:34]([C:44]3[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=3)=[CH:39][CH:38]=2)(=[O:42])=[O:41])[CH2:12][CH2:11][S:10]1)=[O:15])([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:19]1[CH:20]=[CH:21][CH:16]=[CH:17][CH:18]=1

参加物

5

反応物 4

HCID 7036BenzhydrylamineHCID 74192(1,1'-Biphenyl)-4-sulphonyl chlorideHCID 46440943-(tert-Butoxycarbonyl)-1,3-thiazolidine-2-carboxylic acidHCID 6506582Benzophenone, 4-nitro-, oxime

生成物 1

HCID 10311490N-benzhydryl-3-([1,1'-biphenyl]-4-ylsulfonyl)-1,3-thiazolidine-2-carboxamide

実験手順

Following the general solid phase method as outlined Example 33, starting from 3-(tert-butoxy-carbonyl)-1,3-thiazolidine-2-carboxylic acid, Kaiser oxime resin, 1,1′-biphenyl-4-sulfonyl chloride and benzhydrylamine, the title compound was obtained in 98.5% purity by HPLC.

出典と根拠

ORDレコード
ord-ad7fb46b62bd432a96d0fea982e55e96
出典データセット
uspto-grants-2013_04
特許番号
US08415480B2

関連ノート

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