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1H-Pyrrolo(2,3-b)pyridine → 3-[3-(4-chloro-benzyloxy)-2-ethoxy-benzyl]1H-pyrrolo[2,3-b]pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1H-Pyrrolo(2,3-b)pyridine | HCID 9222 | — |
| 反応物 | 1,1,1-Trifluoro-2-iodoethane | HCID 67709 | — |
| 反応物 | 4-Chloro-2-fluorobenzyl bromide | HCID 2736551 | — |
| 反応物 | Oxazole, 4,5-dihydro-4-ethyl-2-((4-methoxyphenyl)methyl)-, (+-)- | HCID 3041214 | — |
| 反応物 | 5-methoxy-1H-pyrrolo[2,3-b]pyridine | HCID 10307871 | — |
| 反応物 | [3-(4-chloro-2-fluoro-benzyloxy)-2-ethoxy-phenyl]-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanone | HCID 58086972 | — |
| 生成物 | 3-[3-(4-chloro-benzyloxy)-2-ethoxy-benzyl]1H-pyrrolo[2,3-b]pyridine | HCID 58087711 | — |
反応手順
were prepared following the protocol of Scheme 71, substituting iodoethane with iodomethane in Step 3 to provide P-1891, or substituting iodoethane with 2-iodo-1,1,1-trifluoroethane in Step 3 to provide P-2076, or substituting 4-chlorobenzyl bromide 557 with 4-chloro-2-fluoro-benzyl bromide in Step 1 and 7-azaindole 94 with 5-methoxy-7-azaindole in Step 4 to provide P-2016. MS(ESI) [M+H+]+=393.4 (P-1891), 461.08 (P-2076), and 455.2 (P-2016).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08415469B2 |
| 出典データセット | uspto-grants-2013_04 |
| ORD ID | ord-719c9062d7554d7d8a61bc71af41d6af |
| 出典メモ | uspto-grants-2013_04 |