3-Phenoxy-hexahydro-pyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester → 3-Phenoxy-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid tert-butyl ester

HRID 1965160ノート

反応式

HRID 1965160 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH:11]([O:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:10]2[N:20](C(OCC3C=CC=CC=3)=O)[CH2:21][CH2:22][CH:9]12)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH:11]([O:13][C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:10]2[NH:20][CH2:21][CH2:22][CH:9]12)=[O:7])([CH3:4])([CH3:2])[CH3:3]

参加物

3

反応物 1

HCID 676086123-Phenoxy-hexahydro-pyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester

生成物 1

HCID 675137713-Phenoxy-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid tert-butyl ester

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A 500 mL Parr bottle was charged with crude 12 (370 mg, 0.84 mmol) and 5% Pd-on-carbon (50 mg) in reagent grade MeOH (10 mL). The mixture was pressurized to 50 PSI H2 then shaken for 1 h. The catalyst was removed by filtration through Celite® and the solids were washed with MeOH and EtOAc. The filtrate was concentrated in vacuo to afford 256 mg (quant.) of 13 which was used without further purification.

後処理

  1. customThe catalyst was removed by filtration through Celite®
  2. washthe solids were washed with MeOH and EtOAc
  3. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-d0aca1a1b5cd414cad83e9b047184c45
出典データセット
uspto-grants-2013_04
特許番号
US08415486B2

反応ノート

読み込み中…