2-Chloroethyl isocyanate → 1-But-3-ynyl-3-(2-chloro-ethyl)-urea

HRID 1965960

反応式

HRID 1965960 の反応式
[Cl:1][CH2:2][CH2:3][N:4]=[C:5]=[O:6].[CH2:7]([NH2:11])[CH2:8][C:9]#[CH:10]>C(OCC)C>[CH2:7]([NH:11][C:5]([NH:4][CH2:3][CH2:2][Cl:1])=[O:6])[CH2:8][C:9]#[CH:10]

参加物

4

反応物 2

HCID 160352-Chloroethyl isocyanateHCID 10034574But-3-yn-1-amine

生成物 1

HCID 597873661-But-3-ynyl-3-(2-chloro-ethyl)-urea収率 100%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

Add chloroethyl isocyanate (5.25 g, 50 mmol) dropwise to a solution of but3-ynyl-amine (3.4 g, 50 mmol) (prepared by following the procedure described in Tetrahedron Lett. 1987, 43, 5145) in ethyl ether (100 mL). Stir the suspension for 30 min and filter the solid to obtain the desired intermediate (8.7 g, 100%).

後処理

  1. customprepared
  2. filtrationfilter the solid

出典と根拠

ORDレコード
ord-7a5f8d6b5fc64492901a3aff656875a6
出典データセット
uspto-grants-2013_04
特許番号
US08420631B2

関連ノート

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