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HRID 1966158作成日：2026年10月27日
1,1-Bis(propan-2-yl) 3,3-dimethoxycyclobutane-1,1-dicarboxylate → 1,1-Bis(propan-2-yl) 3-oxocyclobutane-1,1-dicarboxylate
https://huagongshe.com/reaction/1966158
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1,1-Bis(propan-2-yl) 3,3-dimethoxycyclobutane-1,1-dicarboxylate | HCID 4913359 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 溶媒 | Trifluoroacetic acid water | HCID 22392675 | — |
| 生成物 | 1,1-Bis(propan-2-yl) 3-oxocyclobutane-1,1-dicarboxylate | HCID 4913357 | 99.1% |
反応手順
A mixture of diisopropyl 3,3-dimethoxycyclobutane-1,1-dicarboxylate (3 g, 0.01 mol) in 20 mL of trifluoroacetic acid-water (95:5) was stirred at 0° C. for 4 h. The reaction was diluted with EtOAc, washed with water, saturated NaHCO3 solution, and brine, dried over MgSO4 and evaporated to give crude product (2.4 g) as yellow oil, which was used directly in the next step. H NMR (CDCl3, 400 MHz) δ 5.07 (2H, h, J=6.8 Hz), 3.54 (4H, s), 1.23 (12H, d, J=6.8 Hz) ppm.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08420629B2 |
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| 出典データセット | uspto-grants-2013_04 |
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| ORD ID | ord-2a13090c981f4d908f0a8ebc045a16ec |
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| 出典メモ | uspto-grants-2013_04 |
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