Water → (8-Bromo-2-methylquinolin-4-yl)-(3,4-dichlorobenzyl)-amine

HRID 1966510ノート

反応式

HRID 1966510 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([CH3:12])[CH:8]=[C:7]2Cl.[Cl:14][C:15]1[CH:16]=[C:17]([CH:20]=[CH:21][C:22]=1[Cl:23])[CH2:18][NH2:19].O>CS(C)=O>[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([CH3:12])[CH:8]=[C:7]2[NH:19][CH2:18][C:17]1[CH:20]=[CH:21][C:22]([Cl:23])=[C:15]([Cl:14])[CH:16]=1

参加物

5

反応物 3

HCID 962WaterHCID 1608Benzenemethanamine, 3,4-dichloro-HCID 7684838-Bromo-4-chloro-2-methylquinoline

生成物 1

HCID 59474780(8-Bromo-2-methylquinolin-4-yl)-(3,4-dichlorobenzyl)-amine収率 20.2%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

8-Bromo-4-chloro-2-methylquinoline (4.50 g, 17.5 mmole) and 3,4-dichlorobenzylamine (6.30 g, 35.8 mmole) in dimethylsulfoxide (6 mL) were stirred at 140° C. for 2 h in a microwave oven. Water was added and the mixture was decanted to obtain an oily residue. The residue was washed with ethyl acetate to give a white solid (1.40 g, 20%).

後処理

  1. customthe mixture was decanted
  2. customto obtain an oily residue
  3. washThe residue was washed with ethyl acetate

出典と根拠

ORDレコード
ord-8925cd82dbd547c0a035151219b62daf
出典データセット
uspto-grants-2013_04
特許番号
US08420670B2

反応ノート

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