6-(2,2-Difluoro-2-phenylethoxy)-1-hexanamine → {6-[2,2-Difluoro-2-(3-methylphenyl)ethoxy]hexyl}amine

反応式

[F:1][C:2]([F:29])([C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH3:28])[CH:23]=1)[CH2:3][O:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][N:11]1C(=O)C2C(=CC=CC=2)C1=O.FC(F)(C1C=CC=CC=1)COCCCCCCN>>[F:1][C:2]([F:29])([C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH3:28])[CH:23]=1)[CH2:3][O:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH2:11]

参加物

反応物 2

HCID 509930806-(2,2-Difluoro-2-phenylethoxy)-1-hexanamine

HCID 672465922-{6-[2,2-Difluoro-2-(3-methylphenyl)ethoxy]hexyl}-1H-isoindole-1,3(2H)-dione

生成物 1

HCID 67247388{6-[2,2-Difluoro-2-(3-methylphenyl)ethoxy]hexyl}amine

実験手順

Obtained from Intermediate 31 (4.0 g, 14.4 mmol) by the procedure described in Intermediate 9. {6-[2,2-Difluoro-2-(3-methylphenyl)ethoxy]hexyl}amine was obtained (1.93 g, 50%) as oil.

出典と根拠

ORDレコード: ord-c388be7790604d948ca87547ab8b4f21
出典データセット: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08420669B2

反応ノート

読み込み中…