Ethyl 4,4-difluoro-4-phenylbutanoate → Ethyl 4,4,5,5-tetrafluoro-6-(3-phenylpropoxy)hexanoate

反応式

[F:1][C:2]([F:24])([C:10]([F:23])([F:22])[CH2:11][O:12][CH2:13]/[CH:14]=[CH:15]/[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)/[CH:3]=[CH:4]/[C:5]([O:7][CH2:8][CH3:9])=[O:6].FC(F)(C1C=CC=CC=1)CCC(OCC)=O>>[F:1][C:2]([F:24])([C:10]([F:22])([F:23])[CH2:11][O:12][CH2:13][CH2:14][CH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)[CH2:3][CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6]

参加物

反応物 2

HCID 67245996Ethyl 4,4-difluoro-4-phenylbutanoate

HCID 86658309Ethyl (2E)-4,4,5,5-tetrafluoro-6-{[(2E)-3-phenylprop-2-en-1-yl]oxy}-hex-2-enoate

生成物 1

HCID 86658312Ethyl 4,4,5,5-tetrafluoro-6-(3-phenylpropoxy)hexanoate

実験手順

Obtained from Intermediate 39 (1.2 g, 3.46 mmol) by the procedure described in Intermediate 21. Ethyl 4,4,5,5-tetrafluoro-6-(3-phenylpropoxy)hexanoate was obtained (1.0 g, 82%) as oil.

出典と根拠

ORDレコード: ord-86aa78d0fce14300a4b36391ed36613d
出典データセット: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08420669B2

反応ノート

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