2,2-Difluoro-4-phenylbutan-1-ol → 2,2-Difluoro-2-(3-methoxyphenyl)ethan-1-ol

反応式

[F:1][C:2]([F:16])([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[CH:9]=1)[C:3](OCC)=[O:4].FC(F)(CCC1C=CC=CC=1)CO>>[F:1][C:2]([F:16])([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[CH:9]=1)[CH2:3][OH:4]

参加物

反応物 2

HCID 184257752,2-Difluoro-4-phenylbutan-1-ol

HCID 39058305Ethyl Difluoro-(3-methoxyphenyl)acetate

生成物 1

HCID 672447182,2-Difluoro-2-(3-methoxyphenyl)ethan-1-ol

実験手順

Obtained from Intermediate 67 (4.35 g, 19 mmol) by the procedure described in Intermediate 2. The title compound was obtained (3.19 g, 90%) as oil.

出典と根拠

ORDレコード: ord-91a6cffa834a4b2c935f83b7f51625e7
出典データセット: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08420669B2

反応ノート

読み込み中…