Allyl 2,2-difluoro-2-phenylethyl ether → 3-(2,2-Difluoro-2-phenylethoxy)propan-1-ol

HRID 1966657ノート

反応式

HRID 1966657 の反応式
[F:1][C:2]([F:14])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH2:3][O:4][CH2:5][CH:6]=[CH2:7].C1(CCCC[O:25]CCCO)C=CC=CC=1>>[F:1][C:2]([F:14])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH2:3][O:4][CH2:5][CH2:6][CH2:7][OH:25]

参加物

3

反応物 2

HCID 67245471Allyl 2,2-difluoro-2-phenylethyl etherHCID 672465283-(4-Phenylbutoxy)propan-1-ol

生成物 1

HCID 672459503-(2,2-Difluoro-2-phenylethoxy)propan-1-ol収率 96%

実験手順

Obtained from Intermediate 80 (10.6 g, 53 mmol) by the procedure described in Intermediate 12. Purification by column chromatography with silica gel eluting with ethyl acetate/n-hexane (from 1:4 to pute ethyl acetate) gave the title compound (10.7 g, 96%) as oil.

後処理

  1. customPurification by column chromatography with silica gel eluting with ethyl acetate/n-hexane (from 1:4 to pute ethyl acetate)

出典と根拠

ORDレコード
ord-f78d787b21954680ac0886ca143c3fb2
出典データセット
uspto-grants-2013_04
特許番号
US08420669B2

反応ノート

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