3-(2,2-Difluoro-2-phenylethoxy)propan-1-ol → 3-(2,2-Difluoro-2-phenylethoxy)propanal

HRID 1966658ノート

反応式

HRID 1966658 の反応式
[F:1][C:2]([F:15])([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH2:3][O:4][CH2:5][CH2:6][CH2:7][OH:8].C1(CCCCOCCC=O)C=CC=CC=1>>[F:1][C:2]([F:15])([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH2:3][O:4][CH2:5][CH2:6][CH:7]=[O:8]

参加物

3

反応物 2

HCID 672459503-(2,2-Difluoro-2-phenylethoxy)propan-1-olHCID 866583073-(4-Phenylbutoxy)propionaldehyde

生成物 1

HCID 866583133-(2,2-Difluoro-2-phenylethoxy)propanal収率 60.3%

実験手順

Obtained from Intermediate 81 (3.0 g, 14.4 mmol) by the procedure described in Intermediate 13. Purification by column chromatography with silica gel eluting with methylene chloride gave the title compound (1.86 g, 60%) as oil.

後処理

  1. customPurification by column chromatography with silica gel eluting with methylene chloride

出典と根拠

ORDレコード
ord-9e98ee0d72ee4f88bf2264d780f5ceeb
出典データセット
uspto-grants-2013_04
特許番号
US08420669B2

反応ノート

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