1-(2,2-Difluoro-2-phenylethoxy)hept-6-en-3-ol → 1-(2,2-Difluoro-2-phenylethoxy)hept-6-en-3-one
反応式
[F:1][C:2]([F:19])([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:3][O:4][CH2:5][CH2:6][CH:7]([OH:12])[CH2:8][CH2:9][CH:10]=[CH2:11].C1(CCCCOCCC=O)C=CC=CC=1>>[F:1][C:2]([F:19])([C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)[CH2:3][O:4][CH2:5][CH2:6][C:7](=[O:12])[CH2:8][CH2:9][CH:10]=[CH2:11]参加物
3
実験手順
Obtained from Intermediate 83 (4.3 g, 15.8 mmol) by the procedure described in Intermediate 13. Purification by column chromatography with silica gel eluting with ethyl acetate/n-hexane (1:5) gave the title compound (1.82 g, 43%) as oil.
後処理
- customPurification by column chromatography with silica gel eluting with ethyl acetate/n-hexane (1:5)
出典と根拠
- ORDレコード
- ord-f9bae78385484de4bf868462171218cb
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08420669B2
反応ノート
読み込み中…