Urea → 5-Fluoroisoindoline-1,3-dione
反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=O)[O:8][C:6](=[O:7])[C:5]2=[CH:11][CH:12]=1.[NH2:13]C(N)=O>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:11][CH:12]=1)[C:6](=[O:7])[NH:13][C:9]2=[O:8]参加物
4
実験手順
To 4-fluorophthalic anhydride (5.0 g, 30.10 mmol) in toluene (15 mL) is added urea (2.1 g). The reaction mixture is stirred at refluxed for 16 h. The reaction mixture is allowed to cool to room temperature, concentrated under reduced pressure and triturated with H2O (250 mL) to afford 5-fluoro-isoindole-1,3-dione (5.0 g, 100%) as a white solid.
後処理
- temperatureat refluxed for 16 h
- concentrationconcentrated under reduced pressure
- customtriturated with H2O (250 mL)
出典と根拠
- ORDレコード
- ord-4fbb8245889046fba2c7849229bb340b
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08420655B2
反応ノート
読み込み中…