Diphenyl Ether → HCID 178469630、化合物
反応式
C1(OC2C=CC=CC=2)C=CC=CC=1.[CH3:14][O:15][C:16]1[CH:40]=[CH:39][C:19]([CH2:20][N:21]2[C:25]([NH:26][CH:27]=[C:28]([C:34]([O:36][CH2:37][CH3:38])=[O:35])[C:29](OCC)=[O:30])=[CH:24][CH:23]=[N:22]2)=[CH:18][CH:17]=1>C(O)C>[OH:30][C:29]1[C:28]([C:34]([O:36][CH2:37][CH3:38])=[O:35])=[CH:27][N:26]=[C:25]2[N:21]([CH2:20][C:19]3[CH:39]=[CH:40][C:16]([O:15][CH3:14])=[CH:17][CH:18]=3)[N:22]=[CH:23][C:24]=12参加物
4
反応条件
- 温度
- 45 °C
実験手順
Diphenyl ether (180 ml) was heated to about 230° C. (Internal temperature 200-210° C.) under inert atmosphere in a round bottom flask fitted with distillation set and a solution of diethyl ({[1-(4-methoxybenzyl)-1H-pyrazol-5-yl]amino}methylidene)propanedioate (85 gm, 0.227 mol) (example 2) in absolute ethanol (130 ml) was added dropwise. The reaction mixture was heated for about 2 hours. Volatile solubles were distilled out. The mixture was cooled to 45° C. and methanol (150 ml) was added dropwise. Solid, which precipitated out was filtered and washed with methanol and hexane and dried under vacuum.