Carbon tetrabromide → 2-(Bromomethyl)-5,8-dioxaspiro[3.4]octane
反応式
C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[CH2:20]1[C:23]2([O:27][CH2:26][CH2:25][O:24]2)[CH2:22][CH:21]1[CH2:28]O.[Br:30]C(Br)(Br)Br>ClCCl>[Br:30][CH2:28][CH:21]1[CH2:22][C:23]2([O:27][CH2:26][CH2:25][O:24]2)[CH2:20]1参加物
5
実験手順
Triphenylphosphine (6.28 gm, 24 mmol) in dichloromethane was added drop wise to a solution of 5,8-dioxaspiro[3.4]oct-2-ylmethanol (2.3 gm, 16 mmol) (step d) and tetrabromomethane (6.62 gm, 20 mmol) in dichloromethane. The reaction mixture was stirred at room temperature for about 6 hours. The solvent was removed under reduced pressure and the residue was extracted with diethyl ether. The organic layer was concentrated under reduced pressure to get a crude product, which was purified by column chromatography.
後処理
- customThe solvent was removed under reduced pressure
- extractionthe residue was extracted with diethyl ether
- concentrationThe organic layer was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-27b029d0d56d47e8b60325e2660a95c2
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08420666B2
反応ノート
読み込み中…