3-Chloro-2,6-difluorobenzaldehyde → HCID 178517957、化合物

HRID 1967128ノート

反応式

HRID 1967128 の反応式
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[N:3]=[CH:2]1.[Cl:11][C:12]1[C:13]([F:21])=[C:14]([C:17]([F:20])=[CH:18][CH:19]=1)[CH:15]=O.[O:22]([C:24]#[N:25])[K].Cl.N1C=CC=CC=1.[N+:33]([CH:35]1[C:44]2[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=2)[CH2:38][CH2:37][CH2:36]1)#[C-:34]>CO>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[CH:15]([C:14]4[C:17]([F:20])=[CH:18][CH:19]=[C:12]([Cl:11])[C:13]=4[F:21])[C:34](=[N:33][CH:35]4[C:44]5[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=5)[CH2:38][CH2:37][CH2:36]4)[NH:25][C:24]3=[O:22])=[CH:9][C:4]=2[N:3]=[CH:2]1

参加物

7

反応物 5

HCID 7363383-Chloro-2,6-difluorobenzaldehydeHCID 27594691,2,3,4-Tetrahydro-1-isocyanonaphthaleneHCID 10176127Pyridinium chlorideHCID 178418250HCID 178418250、化合物HCID 178507353HCID 178507353、化合物

生成物 1

HCID 178517957HCID 178517957、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

1H-Benzoimidazol-5-ylamine (1 mmol) and 3-Chloro-2,6-difluorobenzaldehyde (1 mmol) were combined in methanol (2 ml, dry). After 2 hours 2 ml of a solution of KOCN (KSCN) (2 mmol) and Pyridinehydrochloride (2 mmol) in MeOH is added was added. Finally 1-Isocyano-1,2,3,4-tetrahydro-naphthalene (1 mmol) is added. The reaction was stirred at room temperature for 48 h. After evaporation of the solvent the residue was purified with chromatographic methods.

後処理

  1. additionwas added
  2. customAfter evaporation of the solvent the residue
  3. customwas purified with chromatographic methods

出典と根拠

ORDレコード
ord-f10f4d3cd89d4ed59e64d655e59fada0
出典データセット
uspto-grants-2013_04
特許番号
US08420684B2

反応ノート

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