4-{[(Benzyloxy)carbonyl]amino}-5-methoxy-2,2-dimethyl-3-oxopentanoate → HCID 59556989、化合物
反応式
C(OC([NH:11][CH:12]([CH2:21][O:22][CH3:23])[C:13](=[O:20])[C:14]([CH3:19])([CH3:18])[C:15]([O-])=[O:16])=O)C1C=CC=CC=1>CO.[C].[Pd]>[CH3:23][O:22][CH2:21][CH:12]1[NH:11][C:15](=[O:16])[C:14]([CH3:19])([CH3:18])[C:13]1=[O:20]参加物
4
実験手順
To a solution of 4-{[(benzyloxy)carbonyl]amino}-5-methoxy-2,2-dimethyl-3-oxopentanoate (10.2 g) in methanol (100 mL) was added 10% palladium carbon (containing 50% water, 3.1 g), and the mixture was stirred overnight under a hydrogen atmosphere. Palladium carbon was filtered off, and the filtrate was concentrated under reduced pressure. The obtained solid was washed with hexane to give the title compound as colorless crystals (yield: 4.16 g, 84%).
後処理
- filtrationPalladium carbon was filtered off
- concentrationthe filtrate was concentrated under reduced pressure
- washThe obtained solid was washed with hexane
出典と根拠
- ORDレコード
- ord-e1a865582e4a45029bce5321d6fdf2aa
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08420694B2
反応ノート
読み込み中…