Dimethylformamide dimethyl acetal → Ethyl 2-(5-bromo-2,4-dimethoxybenzoyl)-3-dimethylaminoacrylate

HRID 1967449

反応式

HRID 1967449 の反応式
[Br:1][C:2]1[C:3]([O:18][CH3:19])=[CH:4][C:5]([O:16][CH3:17])=[C:6]([C:8](=[O:15])[CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:7]=1.CO[CH:22](OC)[N:23]([CH3:25])[CH3:24]>C1(C)C=CC=CC=1>[Br:1][C:2]1[C:3]([O:18][CH3:19])=[CH:4][C:5]([O:16][CH3:17])=[C:6]([CH:7]=1)[C:8]([C:9](=[CH:22][N:23]([CH3:25])[CH3:24])[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[O:15]

参加物

4

反応物 2

HCID 78373Dimethylformamide dimethyl acetalHCID 25023667Ethyl 3-(5-bromo-2,4-dimethoxyphenyl)-3-oxopropionate

生成物 1

HCID 66985486Ethyl 2-(5-bromo-2,4-dimethoxybenzoyl)-3-dimethylaminoacrylate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

反応条件

温度
95 °C

実験手順

Under a nitrogen atmosphere, ethyl 3-(5-bromo-2,4-dimethoxyphenyl)-3-oxopropionate (52.8 g) obtained in Step 3 of Example 1 and N,N-dimethylformamide dimethyl acetal (44.6 g) were dissolved in toluene. The solution was stirred at 95° C. for 16 hr, and the completion of the reaction was confirmed by HPLC. The reaction mixture was cooled to room temperature to give a solution of ethyl 2-(5-bromo-2,4-dimethoxybenzoyl)-3-dimethylaminoacrylate in toluene. The reaction mixture was directly used in the next step.

後処理

  1. temperatureThe reaction mixture was cooled to room temperature

出典と根拠

ORDレコード
ord-a3821cee8a0a43b9ad698622ad32aaa8
出典データセット
uspto-grants-2013_04
特許番号
US08420821B2

関連ノート

読み込み中…