2-Fluoro-4-(methoxymethoxy)-1-nitrobenzene → 2-Fluoro-4-(methoxymethoxy)aniline
反応式
[F:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][O:10][CH3:11])[CH:5]=[CH:4][C:3]=1[N+:12]([O-])=O.[H][H]>[C].[Pd].C(O)C>[F:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][O:10][CH3:11])[CH:5]=[CH:4][C:3]=1[NH2:12]参加物
5
実験手順
10% Palladium-carbon (390 mg) as a catalyst was added to an ethanol (100 mL) solution of 2-fluoro-4-(methoxymethoxy)-1-nitrobenzene (3.86 g), and stirred overnight in a hydrogen atmosphere at room temperature. The catalyst was removed through filtration, the solvent was evaporated off under reduced pressure, and the resulting residue was purified through silica gel column chromatography (methanol/chloroform=from 0% to 20%, gradient) to give the entitled compound (2.40 g, 73%) as a brown oily substance.
後処理
- customThe catalyst was removed through filtration
- customthe solvent was evaporated off under reduced pressure
- customthe resulting residue was purified through silica gel column chromatography (methanol/chloroform=from 0% to 20%, gradient)
出典と根拠
- ORDレコード
- ord-fd2e952d47e043c28f0253db39672f97
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08420823B2
反応ノート
読み込み中…