Sodium ethoxide → 2-Ethoxy-N-[4-(2-furyl)-5-(tetrahydropyran-4-ylcarbonyl)thiazol-2-yl]acetamide

HRID 1967839ノート

反応式

HRID 1967839 の反応式
[O-:1][CH2:2][CH3:3].[Na+].Br[CH2:6][C:7]([NH:9][C:10]1[S:11][C:12]([C:20]([CH:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)=[O:21])=[C:13]([C:15]2[O:16][CH:17]=[CH:18][CH:19]=2)[N:14]=1)=[O:8]>C(O)C>[CH2:2]([O:1][CH2:6][C:7]([NH:9][C:10]1[S:11][C:12]([C:20]([CH:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)=[O:21])=[C:13]([C:15]2[O:16][CH:17]=[CH:18][CH:19]=2)[N:14]=1)=[O:8])[CH3:3]

参加物

4

反応物 2

HCID 2723922Sodium ethoxideHCID 231445052-Bromo-N-[4-(2-furyl)-5-(tetrahydropyran-4-ylcarbonyl)thiazol-2-yl]acetamide

生成物 1

HCID 231443752-Ethoxy-N-[4-(2-furyl)-5-(tetrahydropyran-4-ylcarbonyl)thiazol-2-yl]acetamide収率 49%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
60 °C

実験手順

Sodium ethoxide (62.0 mg, 0.900 mmol) was dissolved in ethanol (2 mL), and Compound 531 (120 mg, 0.300 mmol) was added thereto, followed by stirring at 60° C. for 3 hours. The reaction mixture was concentrated under reduced pressure, and the resulting residue was purified through silica gel column chromatography (chloroform:methanol=99:1) and crystallized from 2-propanol to afford the entitled Compound 532 (53.4 mg, 49%).

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe resulting residue was purified through silica gel column chromatography (chloroform:methanol=99:1)
  3. customcrystallized from 2-propanol

出典と根拠

ORDレコード
ord-bcd26bfc2f5a4dbebb2d9f64dd527c2f
出典データセット
uspto-grants-2013_04
特許番号
US08420827B2

反応ノート

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