(R)-tert-butyl 3-cyano-1-(cyclopentylamino)-1-oxopropan-2-ylcarbamate → HCID 67224236、化合物

HRID 1968230ノート

反応式

HRID 1968230 の反応式
[C:1]([CH2:3][C@@H:4]([NH:13]C(=O)OC(C)(C)C)[C:5]([NH:7][CH:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1)=[O:6])#[N:2]>C(O)(C(F)(F)F)=O.C(Cl)Cl>[NH2:13][C@H:4]([CH2:3][C:1]#[N:2])[C:5]([NH:7][CH:8]1[CH2:9][CH2:10][CH2:11][CH2:12]1)=[O:6]

参加物

3

反応物 1

HCID 67225088(R)-tert-butyl 3-cyano-1-(cyclopentylamino)-1-oxopropan-2-ylcarbamate

生成物 1

HCID 67224236HCID 67224236、化合物収率 41%

試薬・触媒・溶媒 1

HCID 21863450Trifluoroacetic acid methylene chloride溶媒

実験手順

A mixture of (R)-tert-butyl 3-cyano-1-(cyclopentylamino)-1-oxopropan-2-ylcarbamate and 50% TFA/DCM (10 mL) was stirred for 1 h. Following reaction, the mixture was concentrated to afford the title compound as a clear oil (TFA salt, 0.265 g, 41%). The product was pure by TLC (visualized by ninhydrin stain).

後処理

  1. customreaction
  2. concentrationthe mixture was concentrated

出典と根拠

ORDレコード
ord-0c10f4419b914016bb369fba3931ce62
出典データセット
uspto-grants-2013_04
特許番号
US08420816B2

反応ノート

読み込み中…