化工社化工社 化学情報印刷レポート · 研究参考用
Sodium hydride → 3-(5-(Methylthio)-1,2,4-thiadiazol-3-ylthio)pyrazine-2-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 3-Chloropyrazine-2-carbonitrile | HCID 292465 | — |
| 反応物 | HCID 178503581 | HCID 178503581 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-(5-(Methylthio)-1,2,4-thiadiazol-3-ylthio)pyrazine-2-carbonitrile | HCID 23659518 | — |
反応手順
The title compound was prepared according to Example 1 by using 5-(methylthio)-1,2,4-thiadiazole-3-thiol (328 mg, 2.00 mmol), NaH (60% dispersion in mineral oil, 88 mg, 2.20 mmol), and 3-chloropyrazine-2-carbonitrile (280 mg, 2.00 mmol) in DMF and benzene (6 ml, 1/1) by stirring at room temperature under nitrogen atmosphere for 2 hr.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08426358B2 |
| 出典データセット | uspto-grants-2013_04 |
| ORD ID | ord-8da76539cf98484280bae7dd7741565c |
| 出典メモ | uspto-grants-2013_04 |