化工社化工社 化学情報印刷レポート · 研究参考用
Phthalamide → 2-[3-(4-Fluoro-phenyl)-2-oxo-propyl]-isoindole-1,3-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phthalamide | HCID 6956 | — |
| 反応物 | Potassium | HCID 5462222 | — |
| 反応物 | 1-Chloro-3-(4-fluorophenyl)propan-2-one | HCID 13558293 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-[3-(4-Fluoro-phenyl)-2-oxo-propyl]-isoindole-1,3-dione | HCID 58126972 | — |
反応手順
To a solution of the product of example 23 (85 mg, 0.45 mmol) in DMF (1 mL), under a nitrogen atmosphere, was added potassium salt of phthalamide (96 mg, 0.52 mmol). The resulting mixture was stirred at room temperature for 1 h. The reaction mixture was quenched with a mixture of ice-water and filtered. The slightly pink solid was washed with water to give the titled compound as a white product (79 mg, 62% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08426405B2 |
| 出典データセット | uspto-grants-2013_04 |
| ORD ID | ord-e3fb54c6f7944435b5e1bd64fba2bb64 |
| 出典メモ | uspto-grants-2013_04 |