Potassium Carbonate → N,N-dimethyl-2-(4-nitro-1H-pyrazol-1-yl)ethanamine
反応式
Cl.[CH3:2][N:3]([CH3:7])[CH2:4][CH2:5]Cl.C(=O)([O-])[O-].[K+].[K+].[N+:14]([C:17]1[CH:18]=[N:19][NH:20][CH:21]=1)([O-:16])=[O:15]>CC(C)=O>[CH3:2][N:3]([CH3:7])[CH2:4][CH2:5][N:19]1[CH:18]=[C:17]([N+:14]([O-:16])=[O:15])[CH:21]=[N:20]1参加物
5
実験手順
2-Dimethylaminoethyl chloride hydrochloride (955 mg, 6.63 mmol), potassium carbonate (1.83 g, 8.84 mmol) and 4-nitro-1H-pyrazole (750 mg, 6.63 mmol) were combined in acetone (30 ml) and the reaction was stirred overnight at reflux. After cooling to room temperature, the crude reaction mixture was filtered to remove inorganics, and the filtrate was concentrated to give the product.
後処理
- temperatureat reflux
- customthe crude reaction mixture
- filtrationwas filtered
- customto remove inorganics
- concentrationthe filtrate was concentrated
- customto give the product
出典と根拠
- ORDレコード
- ord-90cd9357aed94eada62ef2c2cd7b9c0b
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08426408B2
反応ノート
読み込み中…