Hydrochloric Acid → 2-Trifluoromethoxy-5-(4-methyl-piperazin-1-yl)-phenylamine trihydrochloride salt

HRID 1968557ノート

反応式

HRID 1968557 の反応式
[F:1][C:2]([F:22])([F:21])[O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]2)=[CH:6][C:5]=1[NH:17]C(=O)C.[ClH:23]>CCO>[ClH:23].[ClH:23].[ClH:23].[F:22][C:2]([F:1])([F:21])[O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]2)=[CH:6][C:5]=1[NH2:17]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 59454307N-[2-trifluoromethoxy-5-(4-methyl-piperazin-1-yl)-phenyl]-acetamide

生成物 1

HCID 866446602-Trifluoromethoxy-5-(4-methyl-piperazin-1-yl)-phenylamine trihydrochloride salt

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of N-[2-trifluoromethoxy-5-(4-methyl-piperazin-1-yl)-phenyl]-acetamide (4.75 g, 15 mmol) in EtOH (100 mL) was treated with HCl 37% (35 mL). After 1 h under reflux the mixture was concentrated and tritured with hexane to give in quantitative yield, 5.74 g of 2-trifluoromethoxy-5-(4-methyl-piperazin-1-yl)-phenylamine trihydrochloride salt.

後処理

  1. temperatureAfter 1 h under reflux the mixture
  2. concentrationwas concentrated and tritured with hexane

出典と根拠

ORDレコード
ord-c263eaed6405445488c8f67687446c68
出典データセット
uspto-grants-2013_04
特許番号
US08426417B2

反応ノート

読み込み中…