Isopropanol → N-(3-ethynylphenyl)-7-nitroquinazolin-4-amine

反応式

Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([N+:12]([O-:14])=[O:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[CH:15](O)([CH3:17])[CH3:16]>>[C:15]([C:17]1[CH:11]=[C:6]([NH:5][C:2]2[C:11]3[C:6](=[CH:7][C:8]([N+:12]([O-:14])=[O:13])=[CH:9][CH:10]=3)[N:5]=[CH:4][N:3]=2)[CH:7]=[CH:8][CH:9]=1)#[CH:16]

参加物

反応物 2

HCID 3776Isopropanol

HCID 8306804-Chloro-7-nitroquinazoline

生成物 1

HCID 16045519N-(3-ethynylphenyl)-7-nitroquinazolin-4-amine収率 94%

実験手順

A mixture of 4-chloro-7-nitroquinazoline (2.0 g, 9.54 mmol), isopropanol (30 mL), and 3-thynylbenzenamine (1.2 g, 10.00 mmol) was refluxed for 5 h. The resulting mixture was cooled to room temperature and refrigerated. The precipitate was filtered out, washed with cold isopropanol several times, and dried in vacuo to give 2.6 g (94%) of N-(3-ethynylphenyl)-7-nitroquinazolin-4-amine as a yellow solid.

後処理

temperaturewas refluxed for 5 h
filtrationThe precipitate was filtered out
washwashed with cold isopropanol several times
customdried in vacuo

出典と根拠

ORDレコード: ord-fe4eafb44eb2404e8a0c414f8710baa3
出典データセット: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08426430B2

反応ノート

読み込み中…

参加物