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HRID 1970080作成日：2026年10月26日
Thiobenzamide → 4-oxo-8-(2-phenyl-thiazol-4-yl)-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline 1-ethyl carboxylate
https://huagongshe.com/reaction/1970080
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Thiobenzamide | HCID 683563 | — |
| 反応物 | 8-(2-bromo-acetyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline 1-ethyl carboxylate | HCID 86627583 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-oxo-8-(2-phenyl-thiazol-4-yl)-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline 1-ethyl carboxylate | HCID 86627596 | 21.1% |
反応手順
54 mg (1.2 mmol) of thiobenzamide is added to a suspension of 124 mg (0.33 mmol) of 8-(2-bromo-acetyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate in 3.5 mL of ethanol. The mixture is stirred at 90° C. for 6 hours then the mixture is cooled to room temperature. The solvent is evaporated, then the product is purified by preparative LCMS. After drying, 29 mg (21%) of 4-oxo-8-(2-phenyl-thiazol-4-yl)-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate is obtained in the form of a beige solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08426437B2 |
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| 出典データセット | uspto-grants-2013_04 |
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| ORD ID | ord-74dbf60bb4d24f90b9aacf5cadb06b38 |
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| 出典メモ | uspto-grants-2013_04 |
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