Potassium Carbonate → 4-Methylamino-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

HRID 1970186

反応式

HRID 1970186 の反応式
[CH3:1][O:2][C:3]([CH:5]1[CH2:9][CH:8]([N:10](C)[C:11](=O)C(F)(F)F)[CH2:7][N:6]1[C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])=[O:4].C(=O)([O-])[O-].[K+].[K+]>CO>[CH3:1][O:2][C:3]([CH:5]1[CH2:9][CH:8]([NH:10][CH3:11])[CH2:7][N:6]1[C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])=[O:4]

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 87365907HCID 87365907、化合物

生成物 1

HCID 534142004-Methylamino-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 4-[Methyl-(2,2,2-trifluoro-acetyl)-amino]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (0.26 g, 0.73 mmol) in methanol (3 mL) was added an aqueous 1.0M solution of potassium carbonate. The reaction mixture was stirred at room temperature for 5 hours and the solvent evaporated in vacuo to yield the title compound which was used directly without further purification.

後処理

  1. customthe solvent evaporated in vacuo

出典と根拠

ORDレコード
ord-71434d124111415ebe4d11ce6267f3f5
出典データセット
uspto-grants-2013_04
特許番号
US08426604B2

関連ノート

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