2-Methoxybenzylamine → 4-[(2-Methoxybenzyl)amino]-6-oxo-2-(3-thienylmethyl)-1,6-dihydropyrimidine-5-carbonitrile
反応式
CS[C:3]1[N:4]=[C:5]([CH2:12][C:13]2[CH:17]=[CH:16][S:15][CH:14]=2)[NH:6][C:7](=[O:11])[C:8]=1[C:9]#[N:10].[CH3:18][O:19][C:20]1[CH:27]=[CH:26][CH:25]=[CH:24][C:21]=1[CH2:22][NH2:23]>>[CH3:18][O:19][C:20]1[CH:27]=[CH:26][CH:25]=[CH:24][C:21]=1[CH2:22][NH:23][C:3]1[N:4]=[C:5]([CH2:12][C:13]2[CH:17]=[CH:16][S:15][CH:14]=2)[NH:6][C:7](=[O:11])[C:8]=1[C:9]#[N:10]参加物
3
実験手順
In analogy to the preparation of Example 1, 100 mg (038 mmol) of 4-(methylsulphanyl)-6-oxo-2-(3-thienylmethyl)-1,6-dihydropyrimidine-5-carbonitrile are reacted with 521 mg (3.80 mmol) of 2-methoxybenzylamine to give 62 mg (46% of theory) of the title compound.
出典と根拠
- ORDレコード
- ord-545902ac5fb44abfbd80fbd5be3edacd
- 出典データセット
- uspto-grants-2013_04