Hydrochloric Acid → (1R)-1-Cyclopropyl-2,2,2-trifluoroethanaminium chloride
反応式
[CH:1]1([C@@H:4]([NH:9]S(C(C)(C)C)=O)[C:5]([F:8])([F:7])[F:6])[CH2:3][CH2:2]1.[ClH:16].O1CCOCC1>CO>[Cl-:16].[CH:1]1([C@@H:4]([NH3+:9])[C:5]([F:8])([F:7])[F:6])[CH2:3][CH2:2]1参加物
5
実験手順
N-[(1R)-1-Cyclopropyl-2,2,2-trifluoroethyl]-2-methylpropane-2-sulfinamide ((S,R), 16.55 g, 68.0 mmol) was dissolved in MeOH (34 ml) and 4 M HCl in dioxane (34.0 ml, 136 mmol) was added. The reaction mixture was allowed to stir for 30 min, and concentrated to half the volume. Ether was added to the mixture, and the resultant precipitate was collected by filtration to give the title compound.
後処理
- concentrationconcentrated to half the volume
- additionEther was added to the mixture
- filtrationthe resultant precipitate was collected by filtration
出典と根拠
- ORDレコード
- ord-e0b6faaaa9b748b3b7bb31eabf50e438
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08431569B2
反応ノート
読み込み中…