Acetic Acid → Methyl 5-formyl-1H-imidazole-4-carboxylate
反応式
[CH2:1]([O:3][CH:4]([O:14]CC)[C:5]1[N:6]=[CH:7][NH:8][C:9]=1[C:10](OC)=[O:11])C.C(O)(=O)C>O>[CH:10]([C:9]1[N:8]=[CH:7][NH:6][C:5]=1[C:4]([O:3][CH3:1])=[O:14])=[O:11]参加物
4
実験手順
To a solution of Intermediate 1B (5.65 g, 24.75 mmol) in water (12 mL) was added acetic acid (49 mL, 0.86 mol). The resulting mixture was stirred under nitrogen for 6 hours. The reaction mixture was azeotroped with toluene and dried under vacuum to give the desired aldehyde, Intermediate 1C in quantitative yield as a white solid, which was used in the next step without further purification.
後処理
- customThe reaction mixture was azeotroped with toluene
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-6db8fdf0aa2e4b39a7a77db972daaa94
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08431565B2
反応ノート
読み込み中…