関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 3-Thiophenecarboxaldehyde | HCID 68135 | — |
| 反応物 | Piperidine, 1-(isocyanoacetyl)- | HCID 6455474 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | trans-(4,5-Dihydro-5-(thiophen-3-yl)oxazol-4-yl)(piperidin-1-yl)methanone | HCID 68961100 | 99% |
反応手順
SLA 09052B was prepared in accordance with method D using thiophene-3-carbaldehyde (0.778 mL, 5.43 mmol), KOH (0.273 mg, 4.94 mmol) in methanol (5 mL) and 2-isocyano-1-(piperidin-1-yl)ethanone SLA 07116B (0.75 g, 4.94 mmol). The solution was stirred for 2 h at 0° C. After work-up (without any further purification) and drying trans-(4,5-dihydro-5-(thiophen-3-yl)oxazol-4-yl)(piperidin-1-yl)methanone SLA 09052B was obtained as a yellow oil (1.29 g, 99% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08431599B2 |
|---|
| 出典データセット | uspto-grants-2013_04 |
|---|
| ORD ID | ord-9f5cf2b18bb7438f9a1c33d28ea63345 |
|---|
| 出典メモ | uspto-grants-2013_04 |
|---|
