1,2-Dichloroethane → Ethyl 2-(benzylamino)propanoate

HRID 1971348ノート

反応式

HRID 1971348 の反応式
Cl.[CH2:2]([NH:4][C@H:5]([C:7]([OH:9])=[O:8])[CH3:6])[CH3:3].[CH:10](=O)[C:11]1C=C[CH:14]=[CH:13][CH:12]=1.Cl[CH2:19][CH2:20]Cl>>[CH2:19]([O:8][C:7](=[O:9])[CH:5]([NH:4][CH2:2][C:3]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH3:6])[CH3:20]

参加物

4

反応物 3

HCID 111,2-DichloroethaneHCID 240BenzaldehydeHCID 86643083Ethyl alanine hydrochloride

生成物 1

HCID 222273Ethyl 2-(benzylamino)propanoate

実験手順

Ethyl alanine hydrochloride (5.5 g, 36.8 mmol), benzaldehyde (7.9 mL, 77.8 mmol), TEA (10.8 mL, 77.8 mmol) and NaBH(Oac)3 (16.5 g, 77.8 mmol) are taken up in 1,2-DCE (200 mL) and stirred at rt for 4 h. The reaction is then partitioned between DCM and saturated aqueous NaHCO3. The organic layer is removed, dried over anhydrous Na2SO4, and concentrated in vacuo. The crude residue is used without further purification. MS (ESI) m/z 208.2 (M+1).

後処理

  1. customThe reaction is then partitioned between DCM and saturated aqueous NaHCO3
  2. customThe organic layer is removed
  3. dry with materialdried over anhydrous Na2SO4
  4. concentrationconcentrated in vacuo
  5. customThe crude residue is used without further purification

出典と根拠

ORDレコード
ord-91c5d55cf2bf4f90b788b3ff63317f6b
出典データセット
uspto-grants-2013_04
特許番号
US08431584B2

反応ノート

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