Ammonium Acetate → 1,3-Thiazol-2-ylthiourea
反応式
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH:6][C:7]([N:9]1C=CN=C1)=[S:8].C([O-])(=O)C.[NH4+]>C(O)C>[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH:6][C:7]([NH2:9])=[S:8]参加物
4
実験手順
A mixture of 65 g (309.1 mmol) N-1,3-thiazole-2-yl-1H-imidazole-1-carbothioamide and 260 g of ammonium acetate were heated to 80° C. in 400 ml ethanol for 1.5 hours; after completion of reaction the solvent was distilled off and water was added to the obtained residue. After extraction with CH2Cl2 and drying of the organic phase with Na2SO4, 59.6 g of the target product were obtained.
後処理
- customafter completion of reaction the solvent
- distillationwas distilled off
- additionwater was added to the obtained residue
- extractionAfter extraction with CH2Cl2
- dry with materialdrying of the organic phase with Na2SO4
出典と根拠
- ORDレコード
- ord-bf35adfbf8df4464b5735cef14e6b56c
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08431604B2
反応ノート
読み込み中…