1-(4-Butylphenyl)-3-chloropropan-1-one → 5-n-Butylindan-1-one

HRID 19715ノート

反応式

HRID 19715 の反応式
[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11](=[O:15])[CH2:12][CH2:13]Cl)=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4]>S(=O)(=O)(O)O>[CH2:1]([C:5]1[CH:10]=[C:9]2[C:8](=[CH:7][CH:6]=1)[C:11](=[O:15])[CH2:12][CH2:13]2)[CH2:2][CH2:3][CH3:4]

参加物

3

反応物 1

HCID 216365181-(4-Butylphenyl)-3-chloropropan-1-one

生成物 1

HCID 149399645-n-Butylindan-1-one

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

A solution of 1-(4-n-butylphenyl)-3-chloropropan-1-one (17.88 g, 79.8 mmol) in concentrated sulphuric acid (69 ml) is heated at 90° C. for 4 hours. After cooling to ambient temperature, the reaction mixture is poured on to ice and extracted with toluene. The combined organic phases are washed with saturated NaHCO3, brine, dried (MgSO4) and evaporated to afford the title compound. NMR δH 0.85 (t J 7.3 3H), 1.28 (sextet J 7.3 2H), 1.56 (quintet J 7.3 2H), 2.6 (m 4H), 3.02 (t J 5 2H), 7.10 (d J 8.3 1H), 7.20 (s 11H), 7.60 (d J 8.3 2H)

後処理

  1. additionthe reaction mixture is poured on to ice
  2. extractionextracted with toluene
  3. washThe combined organic phases are washed with saturated NaHCO3, brine
  4. dry with materialdried (MgSO4)
  5. customevaporated

出典と根拠

ORDレコード
ord-18da456839034051bc86ac3c860c08c1
出典データセット
uspto-grants-2010_06
特許番号
US07745462B2

反応ノート

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