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2-Phenylbutyric Acid → N-(6-Ethoxy-benzothiazol-2-yl)-2-phenyl-butyramide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Phenylbutyric Acid | HCID 7012 | — |
| 反応物 | Amino-6-ethoxybenzothiazole, 2- | HCID 7192 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N-(6-Ethoxy-benzothiazol-2-yl)-2-phenyl-butyramide | HCID 4477449 | — |
反応手順
6-Ethoxy-benzothiazol-2-ylamine (39 mg, 0.20 mmol) and 2-phenyl-butyric acid (33 mg, 0.20 mmol) were dissolved in N,N-dimethylformamide (1 mL) containing triethylamine (84.1 μL, 0.600 mmol). O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (84 mg, 0.22 mmol) was added and the solution was allowed to stir for 16 hours. The crude product was purified by reverse-phase preparative liquid chromatography (17 mg, 0.050 mmol, 25%). ESI-MS m/z calc. 340.1. found 340.9 (M+1)+ Retention time 3.55 minutes.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08431605B2 |
| 出典データセット | uspto-grants-2013_04 |
| ORD ID | ord-3266216ef30d4b8393a1472c4b30e26d |
| 出典メモ | uspto-grants-2013_04 |