Tert-Butylamine → HCID 58124811、化合物

反応式

CS(O[CH2:6][CH2:7][CH2:8][C:9]#[C:10][C:11]1[S:12][CH:13]=[CH:14][CH:15]=1)(=O)=O.[C:16]([NH2:20])([CH3:19])([CH3:18])[CH3:17]>>[C:16]([NH:20][CH2:6][CH2:7][CH2:8][C:9]#[C:10][C:11]1[S:12][CH:13]=[CH:14][CH:15]=1)([CH3:19])([CH3:18])[CH3:17]

参加物

反応物 2

HCID 6385Tert-Butylamine

HCID 581248695-(Thiophen-2-yl)pent-4-ynyl methanesulfonate

生成物 1

HCID 58124811HCID 58124811、化合物

実験手順

A mixture of 210 mg of 2b and 5 ml of tert-butyl amine was stirred for 4 days. The reaction mixture was concentrated and the residue was treated with 20 ml of 1M K2CO3 and the product was extracted into ethyl acetate. The organic layer was washed once with water, dried and concentrated, to provide 250 mg of 2c as a colorless oil.

後処理

concentrationThe reaction mixture was concentrated
additionthe residue was treated with 20 ml of 1M K2CO3
extractionthe product was extracted into ethyl acetate
washThe organic layer was washed once with water
customdried
concentrationconcentrated

出典と根拠

ORDレコード: ord-8e0de67fab5d417e84bc9474c78ac7a0
出典データセット: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08431564B2

反応ノート

読み込み中…

参加物