Potassium Carbonate → 6-Hydroxy-5-oxo-1-(2-oxo-2-piperidin-1-yl-ethyl)-1,5-dihydro-imidazo[1,2-a]pyrimidine-7-carboxylic acid methyl ester
反応式
[CH3:1][O:2][C:3]([C:5]1[N:6]=[C:7]2[N:18]([CH2:19][C:20](=[O:27])[N:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)[CH:17]=[CH:16][N:8]2[C:9](=[O:15])[C:10]=1[O:11]C(=O)C)=[O:4].C([O-])([O-])=O.[K+].[K+]>CO>[CH3:1][O:2][C:3]([C:5]1[N:6]=[C:7]2[N:18]([CH2:19][C:20](=[O:27])[N:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)[CH:17]=[CH:16][N:8]2[C:9](=[O:15])[C:10]=1[OH:11])=[O:4]参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
To a solution of the product of example 1 (3.6 g, 9.57 mmol) in MeOH (40 ml) was added K2CO3 (2.7 g, 19.5 mol). The mixture was stirred at room temperature for about 1 hour and then filtered. The filtrate was concentrated into dryness to give the titled product (crude yield 100%) as yellow solid, which was used directly in next step.