Morpholine → 4-(5-Fluoro-2-methoxy-benzenesulfonyl)-morpholine

HRID 1971834

反応式

HRID 1971834 の反応式
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[F:7][C:8]1[CH:9]=[CH:10][C:11]([O:18][CH3:19])=[C:12]([S:14](Cl)(=[O:16])=[O:15])[CH:13]=1>C(Cl)Cl>[F:7][C:8]1[CH:9]=[CH:10][C:11]([O:18][CH3:19])=[C:12]([S:14]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)(=[O:15])=[O:16])[CH:13]=1

参加物

4

反応物 2

HCID 8083MorpholineHCID 27834095-Fluoro-2-methoxybenzene-1-sulfonyl chloride

生成物 1

HCID 8499944-(5-Fluoro-2-methoxy-benzenesulfonyl)-morpholine収率 91.3%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒3 回

実験手順

To a mixture of morpholine (5.8 g, 66.9 mmol) and TEA (9.3 ml, 66.9 mol) in CH2Cl2 (20 ml) was added dropwise a solution of the product of example 82 (5.0 g, 22 mmol) in CH2Cl2 (10 ml) at 0° C. After stirring at room temperature for one hour, the mixture was diluted with CH2Cl2, washed with water, dried and concentrated under reduced pressure. The resulting residue was purified by column chromatography (PE/EA=10/1) to give the titled compound (5.53 g, yield 90.3%).

後処理

  1. washwashed with water
  2. customdried
  3. concentrationconcentrated under reduced pressure
  4. customThe resulting residue was purified by column chromatography (PE/EA=10/1)

出典と根拠

ORDレコード
ord-6f71ad169f2446b982fba24e3d5a6ee6
出典データセット
uspto-grants-2013_04
特許番号
US08431581B2

関連ノート

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