Carbon tetrabromide → 4-(Bromomethyl)-2-methoxypyridine
反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH2:9]O)[CH:6]=[CH:5][N:4]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:31]>C(Cl)Cl>[Br:31][CH2:9][C:7]1[CH:6]=[CH:5][N:4]=[C:3]([O:2][CH3:1])[CH:8]=1参加物
5
反応条件
- 温度
- 0 °C
実験手順
To a 100-mL round-bottomed flask was added (2-methoxy-4-pyridinyl)methanol (1.52 g, 10.92 mmol), triphenylphosphine (3.15 g, 12.02 mmol, Aldrich, St. Louis, Mo.), and carbon tetrabromide (1.165 mL, 12.02 mmol, Aldrich, St. Louis, Mo.) in DCM (20 mL). The reaction mixture was stirred at 0° C. for 2 h. The solvent was removed in vacuo and the residue was purified by silica gel chromatography, eluting with 20% EtOAc/hexanes to give 4-(bromomethyl)-2-methoxypyridine (1.98 g) as a colorless oil.
後処理
- customThe solvent was removed in vacuo
- customthe residue was purified by silica gel chromatography
- washeluting with 20% EtOAc/hexanes
出典と根拠
- ORDレコード
- ord-b0103361177645e7b7c8047be594a141
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08431563B2
反応ノート
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