1,3-Dibromo-5,5-dimethylhydantoin → HCID 58529590、化合物
反応式
[NH2:1][C:2]1[C:7]2=[CH:8][CH:9]=[C:10]([C:11](=[O:14])[CH2:12][Cl:13])[N:6]2[N:5]=[CH:4][N:3]=1.[Br:15]N1C(C)(C)C(=O)N(Br)C1=O>CN(C=O)C>[NH2:1][C:2]1[C:7]2=[C:8]([Br:15])[CH:9]=[C:10]([C:11](=[O:14])[CH2:12][Cl:13])[N:6]2[N:5]=[CH:4][N:3]=1参加物
4
実験手順
To a solution of 1-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-chloroethanone (500 mg, 2.37 mmol) in DMF (40 mL) at −40° C., was added 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione (339 mg, 1.19 mmol). The reaction was allowed to stir for 1 hr while warming to rt. A precipitate had formed and the reaction was filtered and the precipitate was washed With Et2O to afford 360 mg (52%) of the desired product as a white powder. 1H NMR (300 MHz, DMSO-d6) 8.12 (s, 1 H), 7.53 (s, 1 H), 5.10 (s, 2H); LC-MS (m+H]+=291, RT=2.51 min.