2-Benzyl-6-bromo-2H-indazole → 2-Benzyl-6-chloro-5-fluoro-2H-indazole

HRID 1972716

反応式

HRID 1972716 の反応式
[CH2:1](N1C=C2C(C=C(Br)C=C2)=N1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:18][C:19]1[CH:27]=[C:26]2[C:22]([CH:23]=[N:24][NH:25]2)=[CH:21][C:20]=1[F:28]>>[CH2:1]([N:24]1[CH:23]=[C:22]2[C:26]([CH:27]=[C:19]([Cl:18])[C:20]([F:28])=[CH:21]2)=[N:25]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 585296892-Benzyl-6-bromo-2H-indazoleHCID 585299046-chloro-5-fluoro-1H-indazole

生成物 1

HCID 585295922-Benzyl-6-chloro-5-fluoro-2H-indazole

実験手順

This compound was prepared in a manner similar to the procedure described for the preparation of 2-benzyl-6-bromo-2H-indazole, using 6-chloro-5-fluoro-1H-indazole in place of 6-bromoindazole. 1H-NMR (300 MHz, DMSO-d6) 8.54 (s, 1H), 7.90 (d, 1H), 7.71 (d, 1H), 7.36 to 7.29 (m, 5H), 5.64 (s, 2H); ES-MS m/z 261.0 [M+H]+, RT (min) 3.56.

後処理

  1. customThis compound was prepared in a manner similar to the procedure
  2. customES-MS m/z 261.0 [M+H]+, RT (min) 3.56

出典と根拠

ORDレコード
ord-08504bf612ff4d49958303b44747c49d
出典データセット
uspto-grants-2013_04
特許番号
US08431695B2

関連ノート

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