HCID 36845230、化合物 → N-methyl-2-piperazin-1-ylacetamide

HRID 1972727

反応式

HRID 1972727 の反応式
C([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]([NH:17][CH3:18])=[O:16])[CH2:10][CH2:9]1)C1C=CC=CC=1>[Pd].CCO>[CH3:18][NH:17][C:15](=[O:16])[CH2:14][N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

参加物

4

反応物 1

HCID 36845230HCID 36845230、化合物

生成物 1

HCID 4962075N-methyl-2-piperazin-1-ylacetamide収率 98.9%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒2 回

実験手順

10% Palladium on carbon (115 mg, 10% by wt.) was placed under an inert atmosphere and suspended in EtOH (5 mL). A solution of 2-(4-benzyl-piperazin-1-yl)-N-methyl-acetamide (1.15 g, 4.65 mmol) dissolved in EtOH (18 mL) was added. The reaction mixture was placed under H2 atmosphere (1 Atm pressure) and stirred overnight. The resulting mixture was filtered through a pad of Celite® and the solvent was concentrated in vacuo to give 723 mg (98.9%) of the title compound as a white solid. 1H-NMR (300 MHz, DMSO-d6) 7.61 (broad s, 1H), 2.80 (s, 2H), 2.68 (t, 4H), 2.59 (d, 3H), 2.31 to 2.26 (m, 4H); ES-MS m/z 158.0 [M+H]+, RT (min) 1.13.

後処理

  1. additionwas added
  2. filtrationThe resulting mixture was filtered through a pad of Celite®
  3. concentrationthe solvent was concentrated in vacuo

出典と根拠

ORDレコード
ord-831faa8a6f864fac96be13c9251261ac
出典データセット
uspto-grants-2013_04
特許番号
US08431695B2

関連ノート

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