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Hexamethylenetetramine → Nordiazepam
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hexamethylenetetramine | HCID 4101 | — |
| 反応物 | Ammonium Hydroxide | HCID 14923 | — |
| 反応物 | 5-Chloro-2-(chloroacetamido)benzophenone | HCID 77635 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Nordiazepam | HCID 2997 | 326.5% |
反応手順
A mixture of ethanol (1100 mls), hexamethylenetetramine (35 g., 0.25 mol), 26% ammonium hydroxide (58 ml), and 2-chloroacetamido-5-chlorobenzophenone (308.2 g., 1.0 mol) were permitted to react as described in Example 11 except that the reflux period was increased from 5 to 7 hours. The reaction product, 7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one (221 g.) isolated in a manner identical with Example 11, was obtained in 81.6% yield, melting point 208.5° to 209° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03996209 |
| 出典データセット | uspto-grants-1976_12 |
| ORD ID | ord-5a34f354b93c4f65965e08277bea0f7c |
| 出典メモ | uspto-grants-1976_12 |